After reaching steady state, samples of arterial blood, mixed venous blood and mixed expired air were taken simultaneously. Tracer amounts of acetone, ether and enflurane were infused continuously into a peripheral vein and a bolus of a mixture of krypton, Freon12 and SF 6 was introduced into the peritoneal cavity. The experiments were performed with dogs which were ventilated artifically with breathing patterns with different post-inspiratory breath holding times ( t a) of 0, 0.5, 1.0 and 2.0 s. In this study we have investigated the effects of breath holding and of the physical properties of gases on four different respiratory dead spaces ( V D): the Fowler, the physiological, the washout and the inert gas dead space.
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